Imaging technique to improve the testicular sperm extraction while reducing...
In the middle of Europe nearly every sixth couple of reproductive age is involuntarily childless iAbout 50% of cases are due to male infertility. In about 10% of all infertile men, azoospermia is...
View ArticleResearchers engineer E. coli to produce new forms of popular antibiotic
Like a dairy farmer tending to a herd of cows to produce milk, researchers are tending to colonies of the bacteria Escherichia coli (E. coli) to produce new forms of antibiotics—including three that...
View ArticleNew anti-microbial compounds evade resistance with less toxicity
New compounds that specifically attack fungal infections without attacking human cells could transform treatment for such infections and point the way to targeted medicines that evade antibiotic...
View ArticleCompany reports antifungal compounds that evade resistance
REVOLUTION Medicines, Inc., a company focused on the discovery and development of innovative drugs derived from natural compounds, announced that progress in antimicrobial drug discovery was published...
View ArticleUsing robots, scientists assemble promising antimicrobial compounds
There's an urgent demand for new antimicrobial compounds that are effective against constantly emerging drug-resistant bacteria. Two robotic chemical-synthesizing machines, named Symphony X and...
View ArticleNew evidence emerges on the origins of life
In the beginning, there were simple chemicals. And they produced amino acids that eventually became the proteins necessary to create single cells. And the single cells became plants and animals. Recent...
View ArticleControlling the function of nerve cells that mediate perception of painful...
Chemical biologists at LMU have synthesized a set of molecules which make it possible to optically control the function of nerve cells that mediate perception of painful stimuli.
View ArticleExploring the role of water in the complex energy landscape of proteins
Water is an incredibly important component of any biological system and understanding its role is crucial when you are analysing biological activity at the macromolecular level, according to Bragg...
View ArticleA microscopic approach to the magnetic sensitivity of animals
Researchers at the University of Tokyo have succeeded in developing a new microscope capable of observing the magnetic sensitivity of photochemical reactions believed to be responsible for the ability...
View ArticlePrecise transplant of a biomolecule to a synthesized molecule
The research group of Prof. Makoto Fujita in the Department of Applied Chemistry, School of Engineering, The University of Tokyo, Prof. Koichi Kato in the Okazaki Institute for Integrative Bioscience,...
View ArticleBiochemists devise new technique for blueprinting cell membrane proteins
Biochemists from Trinity College Dublin have devised a new technique that will make the difficult but critical job of blueprinting certain proteins considerably faster, easier and cheaper.
View ArticleBotulinum neurotoxin A inhibitor developed via all-synthetic click epitope...
Botulinum toxin produced by the bacterium Clostridium botulinum is one of the most potent toxins known to humankind—despite its astonishing career in cosmetics applications to prevent development of...
View ArticleElectron-delivering protein manipulates natural catalyst, changing ideas...
Results: In industry, synthesizing ammonia for fertilizers uses massive amounts of hydrogen, typically generated from fossil fuels, but in nature, the nitrogenase enzyme produces ammonia without added...
View ArticleSmall molecules change biological clock rhythm
A team of chemists and biologists at the Institute of Transformative Bio-Molecules (ITbM), Nagoya University have succeeded in finding new molecules that change the circadian rhythm in mammals by...
View ArticleMolecular docking site of a bacterial toxin identified
Clostridium difficile is a dangerous intestinal bacterium that can cause severe diarrhoea and life-threatening intestinal infections after long-term treatment with antibiotics. The pharmacologists and...
View ArticleBody's response to spicy foods guides design of new pain relief drugs
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body's primary receptor for sensing heat and pain, paving the way for the design of more selective...
View ArticleNew type of drug can target all disease-causing proteins
Current drugs block the actions of only about a quarter of known disease-causing proteins, but Yale University researchers have developed a technology capable of not just inhibiting, but destroying...
View ArticleNew, robust and inexpensive technique for protein analysis in tissues
A new technique to study proteins, which does not require advanced equipment, specialized labs or expensive reagents, has been developed at Uppsala University, Sweden. The technique could be further...
View ArticleChemists find efficient, scalable way to synthesize potential...
Chemists at The Scripps Research Institute (TSRI) have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting...
View ArticleResearchers discover new enzyme, link to iron in vitamin A synthesis
A research team's discovery of new information about how plants synthesize carotenoids, precursors for vitamin A that are essential for plant development and survival, and human health, could help...
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